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Traditional Chinese medicine: potential approaches from modern dynamical complexity theories

null

《医学前沿(英文)》 2016年 第10卷 第1期   页码 28-32 doi: 10.1007/s11684-016-0434-2

摘要:

Despite the widespread use of traditional Chinese medicine (TCM) in clinical settings, proving its effectiveness via scientific trials is still a challenge. TCM views the human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. Such fundamental concepts require investigations using system-level quantification approaches, which are beyond conventional reductionism. Only methods that quantify dynamical complexity can bring new insights into the evaluation of TCM. In a previous article, we briefly introduced the potential value of Multiscale Entropy (MSE) analysis in TCM. This article aims to explain the existing challenges in TCM quantification, to introduce the consistency of dynamical complexity theories and TCM theories, and to inspire future system-level research on health and disease.

关键词: traditional Chinese medicine     quantification     dynamical complexity     system level     balance     modern sciences    

Applications of dynamical complexity theory in traditional Chinese medicine

null

《医学前沿(英文)》 2014年 第8卷 第3期   页码 279-284 doi: 10.1007/s11684-014-0367-6

摘要:

Traditional Chinese medicine (TCM) has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach are not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy (MSE) analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.

关键词: traditional Chinese medicine     Multiscale Entropy     dynamical complexity     system level     applications    

Managing stakeholder dynamics and complexity in mega infrastructure projects

Geoffrey Qiping SHEN, Jin XUE

《工程管理前沿(英文)》 2021年 第8卷 第1期   页码 148-150 doi: 10.1007/s42524-020-0149-6

Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated

《医学前沿(英文)》 2023年 第17卷 第1期   页码 68-74 doi: 10.1007/s11684-022-0955-9

摘要: Most information used to evaluate diabetic statuses is collected at a special time-point, such as taking fasting plasma glucose test and providing a limited view of individual’s health and disease risk. As a new parameter for continuously evaluating personal clinical statuses, the newly developed technique “continuous glucose monitoring” (CGM) can characterize glucose dynamics. By calculating the complexity of glucose time series index (CGI) with refined composite multi-scale entropy analysis of the CGM data, the study showed for the first time that the complexity of glucose time series in subjects decreased gradually from normal glucose tolerance to impaired glucose regulation and then to type 2 diabetes (P for trend < 0.01). Furthermore, CGI was significantly associated with various parameters such as insulin sensitivity/secretion (all P < 0.01), and multiple linear stepwise regression showed that the disposition index, which reflects β-cell function after adjusting for insulin sensitivity, was the only independent factor correlated with CGI (P < 0.01). Our findings indicate that the CGI derived from the CGM data may serve as a novel marker to evaluate glucose homeostasis.

关键词: complexity of glucose time series     continuous glucose monitoring     impaired glucose regulation     insulin secretion and sensitivity     refined composite multi-scale entropy    

Managing Coordination Complexity in the Remanufacturing of Aircraft Engines

Qing Yang,Lu Zheng

《工程管理前沿(英文)》 2016年 第3卷 第2期   页码 158-164 doi: 10.15302/J-FEM-2016022

摘要: The complexity of communication and coordination stemming from teams responsible for adjusting interdependent parameters of components is a fundamental feature in the aircraft engine remanufacturing engineering project. To manage coordination complexity, the features of the remanufacturing process of aircraft engine are analyzed and a systematic method is presented to measure and optimize the dependency between coupled components. Furthermore, quantitative models are built based on Design Structure Matrix (DSM) models to measure dependency strengths related to the parameter features of the components. Also, a two-stage DSM clustering criteria is used to reduce the complexity of an organization. An industrial example is provided to illustrate the proposed models. The results showed that the proposed approach can reduce total coordination complexity.

关键词: remanufacturing engineering project     aircraft engine     coordination complexity     organization optimization     design structure matrix (DSM)    

试析战略创新的复杂性

苗东升

《中国工程科学》 2007年 第9卷 第1期   页码 8-14

摘要:

指明了战略创新研究属于复杂性科学,依据系统学原理诠释创新概念;论述了战略创新的复杂性在 于它自身内含的对立统一;论证了国家战略创新是开放复杂巨系统,并指出驾驭这种复杂性需要建设创新型 国家。

关键词: 战略创新     复杂性     系统思维     创新型国家    

Integrated virtual-design methods for forecasting radiated noise of single cylinder diesel block

GUO Lei, HAO Zhiyong, XU Hongmei, LIU Lianyun

《能源前沿(英文)》 2008年 第2卷 第4期   页码 416-421 doi: 10.1007/s11708-008-0097-z

摘要: The two cycle dynamical results, such as the bearing load, the piston thrust, and the load spatial distribution etc., were obtained by hybrid dynamical simulation of the flexible assembly of the block and crank-train. The finite element model of the block was validated by modal test. The frequency response of the block was calculated using the finite element method (FEM). Finally, the radiated noise such as sound power level and efficiency in the out sound field were obtained using the direct boundary element method (BEM).

关键词: bearing     dynamical     frequency response     dynamical simulation     hybrid dynamical    

动态快速路由查找算法

刘亚林

《中国工程科学》 2002年 第4卷 第7期   页码 60-68

摘要:

给出了动态快速路由查找算法(DFR)的原理和实现。该算法采用特殊的数据结构来构建索引表,能支持动态插入、删除和更新路由;DFR算法最多4次访存,最少2次访存,就能找到完整的路由信息。该算法不仅适用于软件实现,而且由于查找简单,也适合于硬件实现。

关键词: 前缀扩展     DFR     路由     路由查找    

Output tracking control of mobile manipulators based on dynamical sliding-mode control

WUYuxiang, FENG Ying, HU Yueming

《机械工程前沿(英文)》 2007年 第2卷 第1期   页码 110-115 doi: 10.1007/s11465-007-0019-5

摘要: A dynamical sliding-mode controller is devised to track the output of mobile manipulators. During the investigation, firstly a reduced dynamic model considering the dynamics of the driving motor is developed for mobile manipulators. Then, the system is decomposed into four lower-dimensional subsystems by means of diffeomorphism and nonlinear input transformation. Moreover, a design method of the dynamical sliding-mode controller that is applied to the output tracking of mobile manipulators is proposed. The simulation results indicate that the dynamical sliding-mode controller can not only track the given trajectory correctly but also reduce the chattering of sliding-mode control system considerably.

关键词: lower-dimensional     nonlinear     trajectory     tracking     diffeomorphism    

From systematicness to complexity: Fundamental thinking of mega-project management

Zhaohan SHENG, Han LIN

《工程管理前沿(英文)》 2018年 第5卷 第1期   页码 125-127 doi: 10.15302/J-FEM-2018001

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

《医学前沿(英文)》 2018年 第12卷 第4期   页码 361-373 doi: 10.1007/s11684-018-0656-6

摘要:

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypic axis. These cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and relapse. Currently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal phenotypic spectrum. An improved understanding of the dynamic and plastic nature of the EMT program has the potential to yield novel therapies targeting this cellular program that may aid in the management of high-grade malignancies.

关键词: epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

具有脉冲效应的复杂动态网络综述 Review Articles

Xiu-ping HAN, Yong-shun ZHAO, Xiao-di LI

《信息与电子工程前沿(英文)》 2020年 第21卷 第2期   页码 199-219 doi: 10.1631/FITEE.1900456

摘要: 本文回顾具有脉冲效应的复杂动态网络研究工作。将脉冲效应分为脉冲控制与脉冲干扰两个方面,较全面系统地总结具有脉冲效应的复杂动态网络基础性研究结果和最近研究进展。论文主要分5部分,包括复杂动态网络的同步脉冲、失同步脉冲、自适应脉冲同步、牵制脉冲同步以及具有随机和脉冲效应的复杂动态网络。最后,给出结论,并简要叙述具有脉冲效应的复杂动态网络未来研究方向。

关键词: 复杂动态网络;同步脉冲;失同步脉冲;牵制控制;时滞    

An improved low-complexity sum-product decoding algorithm for low-density parity-check codes

Michaelraj Kingston ROBERTS,Ramesh JAYABALAN

《信息与电子工程前沿(英文)》 2015年 第16卷 第6期   页码 511-518 doi: 10.1631/FITEE.1400269

摘要: In this paper, an improved low-complexity sum-product decoding algorithm is presented for low-density parity-check (LDPC) codes. In the proposed algorithm, reduction in computational complexity is achieved by utilizing fast Fourier transform (FFT) with time shift in the check node process. The improvement in the decoding performance is achieved by utilizing an optimized integer constant in the variable node process. Simulation results show that the proposed algorithm achieves an overall coding gain improvement ranging from 0.04 to 0.46 dB. Moreover, when compared with the sum-product algorithm (SPA), the proposed decoding algorithm can achieve a reduction of 42%-67% of the total number of arithmetic operations required for the decoding process.

关键词: Computational complexity     Coding gain     Fast Fourier transform (FFT)     Low-density parity-check (LDPC) codes     Sum-product algorithm (SPA)    

Grasping institutional complexity in infrastructure mega-projects through the multi-level governance

Yi HU, Yun LE, Xinglin GAO, Yongkui LI, Mingqiang LIU

《工程管理前沿(英文)》 2018年 第5卷 第1期   页码 52-63 doi: 10.15302/J-FEM-2018074

摘要: This study analyzes the design and operation of multi-level governance system for the smooth delivery of infrastructure mega-projects with high institutional complexity caused by market transition. From an institutional perspective, this study scrutinizes the structure, elements, and dynamics of the governance system of infrastructure mega-projects and then proposes an integrative framework based on the inductive case study of the Hong Kong-Zhuhai-Macao Bridge mega-project. Multiple evidences of archives, field studies, and interviews related to the case project are triangulated to further analyze the institutional effects, specifically those with government logics and market structures, on the design and operation of the three-level governance system. Results reveal that the co-evolution between governments and markets in China has shaped the vertical levels of the mega-project governance system and has further affected their evolution and operation across various stages of project development. This study contributes to the rapidly emerging research on complex system governance by proposing a systematic model of three-level mega-project governance to enhance the timely delivery of infrastructure mega-projects within budget.

关键词: institutional complexity     multi-level governance     infrastructure mega-project     China    

从复杂性看科学发展观

苗东升

《中国工程科学》 2005年 第7卷 第8期   页码 1-8

摘要:

发展观指人们对社会发展的目标、动力、模式、规律等的根本看法,其复杂性涉及四个层面:在对象层面上,发展观的复杂性源于社会是特殊的开放复杂巨系统;在认知层面上,认知过程的复杂性源于思维巨系统的复杂性与习以为常的还原论和非系统思维带来的曲解;在实践层面上,落实发展观的复杂性源于现实的利益格局、现行体制中的不完善、国际关系的复杂性等因素;在哲学层面上,发展观的复杂性源于发展过程包含的大量对立统一,只有对它们统筹兼顾,确保矛盾各方全面协调发展,才是科学的。

关键词: 科学发展观     复杂性     开放复杂巨系统     对立统一    

标题 作者 时间 类型 操作

Traditional Chinese medicine: potential approaches from modern dynamical complexity theories

null

期刊论文

Applications of dynamical complexity theory in traditional Chinese medicine

null

期刊论文

Managing stakeholder dynamics and complexity in mega infrastructure projects

Geoffrey Qiping SHEN, Jin XUE

期刊论文

Decreasing complexity of glucose time series derived from continuous glucose monitoring is correlated

期刊论文

Managing Coordination Complexity in the Remanufacturing of Aircraft Engines

Qing Yang,Lu Zheng

期刊论文

试析战略创新的复杂性

苗东升

期刊论文

Integrated virtual-design methods for forecasting radiated noise of single cylinder diesel block

GUO Lei, HAO Zhiyong, XU Hongmei, LIU Lianyun

期刊论文

动态快速路由查找算法

刘亚林

期刊论文

Output tracking control of mobile manipulators based on dynamical sliding-mode control

WUYuxiang, FENG Ying, HU Yueming

期刊论文

From systematicness to complexity: Fundamental thinking of mega-project management

Zhaohan SHENG, Han LIN

期刊论文

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

期刊论文

具有脉冲效应的复杂动态网络综述

Xiu-ping HAN, Yong-shun ZHAO, Xiao-di LI

期刊论文

An improved low-complexity sum-product decoding algorithm for low-density parity-check codes

Michaelraj Kingston ROBERTS,Ramesh JAYABALAN

期刊论文

Grasping institutional complexity in infrastructure mega-projects through the multi-level governance

Yi HU, Yun LE, Xinglin GAO, Yongkui LI, Mingqiang LIU

期刊论文

从复杂性看科学发展观

苗东升

期刊论文